[HTML][HTML] CREB-binding protein is a transcriptional coactivator for hepatocyte nuclear factor-4 and enhances apolipoprotein gene expression
H Dell, M Hadzopoulou-Cladaras - Journal of Biological Chemistry, 1999 - ASBMB
Hepatocyte nuclear factor-4 (HNF-4) is a liver-enriched transcription factor that is crucial in
the regulation of a large number of genes involved in glucose, cholesterol, and fatty acid
metabolism and in determining the hepatic phenotype. We have previously shown that HNF-
4 contains transcription activation functions at the N terminus (AF-1) and the C terminus (AF-
2) which work synergistically to confer full HNF-4 activity. Here, we show that HNF-4 recruits
the CREB-binding protein (CBP) coactivator on promoters of genes that contain functional …
the regulation of a large number of genes involved in glucose, cholesterol, and fatty acid
metabolism and in determining the hepatic phenotype. We have previously shown that HNF-
4 contains transcription activation functions at the N terminus (AF-1) and the C terminus (AF-
2) which work synergistically to confer full HNF-4 activity. Here, we show that HNF-4 recruits
the CREB-binding protein (CBP) coactivator on promoters of genes that contain functional …