Protein phosphatase 1 inhibitor-1 deficiency reduces phosphorylation of renal NaCl cotransporter and causes arterial hypotension
N Picard, K Trompf, CL Yang, RL Miller… - Journal of the …, 2014 - journals.lww.com
The thiazide-sensitive NaCl cotransporter (NCC) of the renal distal convoluted tubule (DCT)
controls ion homeostasis and arterial BP. Loss-of-function mutations of NCC cause renal salt
wasting with arterial hypotension (Gitelman syndrome). Conversely, mutations in the NCC-
regulating WNK kinases or kelch-like 3 protein cause familial hyperkalemic hypertension.
Here, we performed automated sorting of mouse DCTs and microarray analysis for
comprehensive identification of novel DCT-enriched gene products, which may potentially …
controls ion homeostasis and arterial BP. Loss-of-function mutations of NCC cause renal salt
wasting with arterial hypotension (Gitelman syndrome). Conversely, mutations in the NCC-
regulating WNK kinases or kelch-like 3 protein cause familial hyperkalemic hypertension.
Here, we performed automated sorting of mouse DCTs and microarray analysis for
comprehensive identification of novel DCT-enriched gene products, which may potentially …