poaldosteronism type 2 (4), is a rare inherited form of low-renin hypertension associated
with hyperkalemia and hyperchloremic metabolic acidosis in patients with a normal GFR
(OMIM no. 145260). This monogenic form of arterial hypertension has excited new interest
since the discovery of a new, unsuspected molecular pathway that is responsible for both
the biochemical abnormalities and the increase in BP observed. Genetic analysis has led to
the identification of mutations in two genes that belong to a new family of kinases, the WNK …