[HTML][HTML] Altered activation of protein kinase PKR and enhanced apoptosis in dystonia cells carrying a mutation in PKR activator protein PACT
PACT is a stress-modulated activator of the interferon-induced double-stranded RNA-
activated protein kinase (PKR). Stress-induced phosphorylation of PACT is essential for
PACT's association with PKR leading to PKR activation. PKR activation leads to
phosphorylation of translation initiation factor eIF2α inhibition of protein synthesis and
apoptosis. A recessively inherited form of early-onset dystonia DYT16 has been recently
identified to arise due to a homozygous missense mutation P222L in PACT. To examine if …
activated protein kinase (PKR). Stress-induced phosphorylation of PACT is essential for
PACT's association with PKR leading to PKR activation. PKR activation leads to
phosphorylation of translation initiation factor eIF2α inhibition of protein synthesis and
apoptosis. A recessively inherited form of early-onset dystonia DYT16 has been recently
identified to arise due to a homozygous missense mutation P222L in PACT. To examine if …
