Integrin-associated protein is a ligand for the P84 neural adhesion molecule
P Jiang, CF Lagenaur, V Narayanan - Journal of Biological Chemistry, 1999 - ASBMB
P84 (also known as SHPS-1, BIT, and SIRP) is a heterophilic adhesive membrane protein
involved in receptor tyrosine kinase signaling that is found at synapses in the mammalian
central nervous system and in non-neural tissues. We have identified a binding partner for
P84 using an expression cloning strategy. Here we report that integrin-associated protein
(IAP/CD47) is a predominant binding partner of P84. Immunohistochemistry reveals a
virtually identical distribution of P84 and IAP in a variety of adult brain regions. Because IAP …
involved in receptor tyrosine kinase signaling that is found at synapses in the mammalian
central nervous system and in non-neural tissues. We have identified a binding partner for
P84 using an expression cloning strategy. Here we report that integrin-associated protein
(IAP/CD47) is a predominant binding partner of P84. Immunohistochemistry reveals a
virtually identical distribution of P84 and IAP in a variety of adult brain regions. Because IAP …
